Alzheimer’s disease has long been considered a neurodegenerative disorder, but recent research suggests it may have infectious origins. Scientists have found evidence linking Porphyromonas gingivalis, the bacteria responsible for gum disease, to the development of Alzheimer’s. This groundbreaking discovery is reshaping how we understand the disease and opening new doors for potential treatments.

Bacteria Found in the Brains of Alzheimer’s Patients

A study found traces of P. gingivalis in the brains of deceased individuals diagnosed with Alzheimer’s. This bacteria, known for causing chronic periodontitis (gum disease), was not only present but had also released toxic enzymes called gingipains. These enzymes are believed to play a role in brain inflammation and damage.

More intriguingly, these bacterial toxins were also found in people who had Alzheimer’s-related brain changes but had not yet developed dementia. This suggests the infection may begin years before symptoms of cognitive decline appear.

How Gum Disease Bacteria May Trigger Alzheimer’s

When researchers infected mice with P. gingivalis, they observed that the bacteria colonized the brain and triggered the production of amyloid beta—a protein strongly linked to Alzheimer’s. This supports the growing hypothesis that Alzheimer’s may not just be a degenerative condition but could also have infectious triggers.

A Potential Breakthrough in Alzheimer’s Treatment

The link between gum disease and Alzheimer’s has led to exciting new treatment possibilities. A biotech company, Cortexyme, has developed an experimental drug called COR388, designed to block gingipains and reduce bacterial infection. Early animal studies have shown promising results, with reductions in both bacterial presence and amyloid beta buildup.

While human trials are still needed, researchers are optimistic. The findings reinforce the importance of maintaining good oral health as a potential protective measure against cognitive decline.

The Importance of Oral Hygiene in Brain Health

With no major advancements in dementia treatment for over 15 years, scientists emphasize the need to explore all possible causes and solutions. While more research is required to fully understand the connection, this study highlights a crucial takeaway: taking care of your teeth may play a significant role in protecting your brain health in the long run.